Cannabidiol: Pharmacokinetics in dogs and cat
spotlight topic:
Pharmacokinetics in dogs and cat
Published 23 April 2023 | Updated 15 March 2024
- Lyons, C. et al. (2024) Pharmacokinetic of two oral doses of a 1:20 THC:CBD Cannabis herbal extract in cats. Frontiers in Veterinary Science, 11. https://www.frontiersin.org/articles/10.3389/fvets.2024.1352495
- Corsato Alvarenga, I., Wilson, K.M. and McGrath, S. (2023) Tolerability of long-term cannabidiol supplementation to healthy adult dogs. Journal of Veterinary Internal Medicine, 38 (1), pp. 326-355. https://doi.org/10.1111/jvim.16949
- Fernández-Trapero, M. et al. (2020) Pharmacokinetics of Sativex® in dogs: Towards a potential cannabinoid-based therapy for canine disorders. Biomolecules, 10 (2), no. 279. https://doi.org/10.3390/biom10020279
- Wakshlag, J.J. et al. (2020) Pharmacokinetics of cannabidiol, cannabidiolic acid, Δ9-tetrahydrocannabinol, tetrahydrocannabinolic acid and related metabolites in canine serum after dosing with three oral forms of hemp extract. Frontiers in Veterinary Science, 7. https://doi.org/10.3389/fvets.2020.00505
- Della Rocca, G. et al. (2022) Pharmacokinetics of cannabidiol following single oral and oral transmucosal administration in dogs. Frontiers in Veterinary Science, 9. https://doi.org/10.3389%2Ffvets.2022.1104152
- Di Salvo, A., Conti, M.B. and della Rocca, G. (2023) Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge. Frontiers in Veterinary Science, 10, https://doi.org/10.3389/fvets.2023.1204526
- Corsato Alvarenga, I. et al. (2023) Cannabidiol plasma determination and pharmacokinetics conducted at beginning, middle and end of long-term supplementation of a broad-spectrum hemp oil to healthy adult dogs. Frontiers in Veterinary Science, 10, no. 1279926. https://doi.org/10.3389/fvets.2023.1279926
- Bartner, L.R. et al. (2018) Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs. Canadian Journal of Veterinary Research, 82 (3), pp. 178-183. Available from: https://europepmc.org/article/MED/30026641 [Accessed 23 April 2023]
- Amstutz, K. et al. (2022) Single dose and chronic oral administration of cannabigerol and cannabigerolic acid‐rich hemp extract in fed and fasted dogs: Physiological effect and pharmacokinetic evaluation. Journal of Veterinary Pharmacology and Therapeutics, 45 (3), pp. 245-254. https://doi.org/10.1111/jvp.13048
- Polidoro, D. et al. (2022) Pharmacokinetics of cannabidiol following intranasal, intrarectal, and oral administration in healthy dogs. Frontiers in Veterinary Science, 9. https://doi.org/10.3389/fvets.2022.899940
- Deabold, K.A. et al. (2019) Single-dose pharmacokinetics and preliminary safety assessment with use of CBD-rich hemp nutraceutical in healthy dogs and cats. Animals, 9 (10), no. 832. https://doi.org/10.3390/ani9100832
- Doran, C.E. et al. (2022) Drug-drug interaction between cannabidiol and phenobarbital in healthy dogs. American Journal of Veterinary Research, 83 (1). https://doi.org/10.2460/ajvr.21.08.0120
- Zamith Cunha, R. et al (2023) Endocannabinoid system receptors at the hip and stifle joints of middle-aged dogs: A novel target for the therapeutic use of cannabis sativa extract in canine arthropathies. Animals, 13 (8), 2833. https://doi.org/10.3390/ani13182833.
- Corsato Alvarenga, I. et al. (2023) Cannabidiol plasma determination and pharmacokinetics conducted at beginning, middle and end of long-term supplementation of a broad-spectrum hemp oil to healthy adult dogs. Frontiers in Veterinary Science, 10, 1279926. https://doi.org/10.3389/fvets.2023.1279926.
- Jukier, T et al. (2023) Disposition of a single oral dose of a cannabidiol medication in healthy cats Frontiers in Veterinary Science, 10. https://doi.org/10.3389/fvets.2023.1181517
- Rozental, A.J. et al. (2023) Pharmacokinetics of escalating single‐dose administration of cannabidiol to cats. Journal of Veterinary Pharmacology and Therapeutics, 46 (1), pp. 25-33. https://doi.org/10.1111/jvp.13100
- Court, M.H. et al. (2023) Cannabidiol and cannabidiolic acid: Preliminary in vitro evaluation of metabolism and drug–drug interactions involving canine cytochrome P‐450, UDP‐glucuronosyltransferase, and P‐glycoprotein. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13403
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