Domain 1 – Defining populations at risk

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Domain 1 – Defining populations at risk

aspirin tablesThe goal of Domain 1 was to establish disorders in which there is an association between disease and thrombosis and sought to determine to which patients antithrombotic medications should be administered. This paper presents a review of the evidence for diseases and risk factors using a standardized Population Exposure Comparison Outcome (PECO) question format was used to investigate whether in dogs or cats (Population, P), the development of a disease (Exposure, E), as opposed to remaining disease free (Comparison, C), was associated with the development of thrombosis (Outcome, O). Risk for thrombosis was further classified as “high,” “moderate,” or “low.”

Of the diseases evaluated, a high risk for thrombosis was identified in dogs with immune mediated haemolytic anaemia or protein-losing nephropathy and in cats with cardiomyopathy. However, it was also noted that it may be appropriate to use antithrombotics in those animals with more than one risk factor for thrombosis.

deLaforcade, A. et al. (2019) Consensus on the rational use of antithrombotics in veterinary critical care (CURATIVE): Domain 1—Defining populations at risk. Journal of Veterinary Emergency and Critical Care, 29 (1), pp. 37-48
[This article can be accessed via RCVS Knowledge Library membership, click here]

American College of Veterinary Emergency and Critical Care (ACVECC) consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE) guidelines under five headings:

Domain 1 – Defining populations at risk

Domain 2 – Defining rational therapeutic usage

Domain 3 – Defining antithrombotic protocols

Domain 4 – Refining and monitoring antithrombotic therapies

Domain 5 – Discontinuation of anticoagulant therapy in small animals

Clinical applications

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Image copyright attribute:
Shane Maritch

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