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Tag: osteoarthritis
Vet examining a dog in a clinic

A prospective, randomized, blinded, placebo-controlled multisite clinical study of bedinvetmab , a canine monoclonal antibody targeting nerve growth factor, in dogs with osteoarthritis

M.J. Corral, H. Moyaert, T. Fernandes, M. Escalada, J.K.S. Tena, R. R. Walters and M.R. Stegemann | Veterinary Anaesthesia and Analgesia | August 2021
The aim of this randomized, double-blind, multicentre study was to evaluate the efficacy and safety of bedinvetmab (Librela; Zoetis), compared to a placebo, for the alleviation of pain associated with osteoarthritis in client-owned dogs (n = 287)…

A Golden Retriever lying on a bed

Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs

M. Krautmann, R. Walters, P. Cole, J. Tena, L.M. Bergeron, J. Messamore, D. Mwangi, S. Rai, P. Dominowski, K. Saad, Y. Zhu, M. Guillot and L. Chouinard | The Veterinary Journal | October 2021
This paper describes the laboratory safety evaluation of bedinvetmab based on three integrated laboratory studies in healthy adult laboratory Beagles…

Efficacy and safety of an anti-nerve growth factor antibody (Frunevetmab) for the treatment of degenerative joint disease-associated chronic pain in cats: A multisite pilot field study

M.E. Gruen, J.A.E. Myers and B. D. X. Lascelles | Frontiers in Veterinary Science | May 2021
The aim of this randomised placebo-controlled, double-blinded trial was to evaluate the safety and efficacy of two administration routes of frunevetmab compared to placebo in the treatment of degenerative joint disease (DJD)-associated pain in client-owned cats…

2021 AAFP Feline Senior Care Guidelines

M. Ray, H.C. Carney, B. Boynton, J. Quimby, S. Robertson, K. St Denis, H. Tuzio and B. Wright | Journal of Feline Medicine and Surgery | June 2021
These consensus guidelines provide information for practitioners on all aspects of the care of senior cats…

Development of a checklist for the detection of degenerative joint disease-associated pain in cats

M. Enomoto, B.D.X. Lascelles and M.E. Gruen | Journal of Feline Medicine and Surgery | March 2020
The aim of this study was to develop a checklist that could be completed by owners and used to identify cats likely to have pain associated with degenerative joint diseases (DJD)…

Chronic pain in cats: Recent advances in clinical assessment

B.P. Monteiro and P.V. Steagall | Journal of Feline Medicine and Surgery | July 2019
This review article considers the recent advances in the assessment of chronic pain in cats, discusses the continuing challenges and offers some thoughts on future perspectives…

Managing pain in common end-of-life conditions

A. Malik and S. Gregersen | The Veterinary Nurse | May 2019
The aim of this article was to consider some of the common end-of-life conditions that cause, or have the potential to cause, pain, and to provide guidance on how best to manage these in practice…